Publications

Wray-Dutra MN, Al Qureshah F, Metzler G, Oukka M, James RG, Rawlings DJ. Activated PIK3CD drives innate B cell expansion yet limits B cell-intrinsic immune responses. J Exp Med. 2018 Oct 1;215(10):2485-2496. doi: 10.1084/jem.20180617. Epub 2018 Sep 7.

Wray-Dutra MN, Chawla R, Thomas KR, Seymour BJ, Arkatkar T, Sommer KM, Khim S, Trapnell C, James RG, Rawlings DJ. Activated CARD11 accelerates germinal center kinetics, promoting mTORC1 and terminal differentiation. J Exp Med. 2018 Sep 3;215(9):2445-2461. doi: 10.1084/jem.20180230. Epub 2018 Aug 20.

James RG, Reeves SR, Barrow KA, White MP, Glukhova VA, Haghighi C, Seyoum D and Debley JS. Deficient Follistatin-like 3 secretion by asthmatic airway epithelium impairs fibroblast regulation and fibroblast-to-myofibroblast transition. (2018) American Journal of Respiratory Cell and Molecular Biology 59(1):104-113.

Hung KL, Meitlis I, Hale M, Chen CY, Sing S, Jackson SW, Miao CH, Khan IF, Rawlings DJ and James RG. Engineering protein-secreting plasma cells by homology-directed repair in primary human B cells. (2018) Molecular Therapy. 26(2):456-67.

Altman MC, Reeves SR, Parker AR, Whalen E, Misura KM, Barrow KA, James RG, Hallstrand TS, Ziegler S and, Debley JS. Interferon response to respiratory syncytial virus by bronchial epithelium from children with asthma is inversely correlated with pulmonary function. (2017) Journal of Allergy and Clinical Immunology 142(2):451-459.

Gorman JA, Hundhausen C, Errett J, Stone A, Allenspach E, Ge Y, Arkatkar T, Clough C, Dai X, Khim S, Pestal K, Liggitt D, Cerosaletti K, Stetson D, James RG, Oukka M, Concannon P, Gale M, Buckner JH, and Rawlings DJ. The A946T variant of the RNA sensor IFIH1 mediates an interferon program that limits viral infection but increases the risk for autoimmunity. (2017) Nature Immunology. 18(7):744-52

Dam EM, Habib T, Chen J, Funk A, Glukhova V, Davis-Pickett M, Wei S, James RG, Buckner JH, Cerosaletti K. The BANK1 SLE-risk variants are associated with alterations in peripheral B cell signaling and development in humans. (2016) Clinical Immunology. 173:171-180.

Tampella G, Kerns HM, Niu D, Singh S, Khim S, Bosch KA, Garrett MG, Moguche A, Evans E, Browning B, Jahan TA, Nacht M, Wolf-Yadlin A, Plebani A, Hamerman JA, Rawlings DJ, James RG. The Tec kinase-regulated phosphoproteome reveals a mechanism for the regulation of inhibitory signals in murine macrophages. (2015) Journal of Immunology 195:246-56. 

Robin NC, Agoston Z, Biechele TL, James RG, Berndt JD, Moon RT. Simvastatin promotes adult hippocampal neurogenesis by enhancing Wnt/β-catenin signaling. (2014) Stem Cell Reports.  2(1):9-17.

James RG, Bosch KA, Kulikauskas RM, Yang PT, Robin NC, Toroni RA, Biechele TL, Berndt JD, von Haller PD, Eng JK, Wolf-Yadlin A, Chien AJ, Moon RT. Protein kinase PKN1 represses Wnt/β-catenin signaling in human melanoma cells. (2013) The Journal of biological chemistry. 288(48):34658-70.

Moore KE, Carlson SM, Camp ND, Cheung P, James RG, Chua KF, Wolf-Yadlin A, Gozani O. A general molecular affinity strategy for global detection and proteomic analysis of lysine methylation. (2013) Molecular cell. 50(3):444-56.

Dai X, James RGHabib T, Singh S, Jackson S, Khim S, Moon RT, Liggitt D, Wolf-Yadlin A, Buckner JH, Rawlings DJ. A disease-associated PTPN22 variant promotes systemic autoimmunity in murine models. (2013) The Journal of clinical investigation. 123(5):2024-36.

Fleming BM, Yelin R, James RG, Schultheiss TM. A role for Vg1/Nodal signaling in specification of the intermediate mesoderm. (2013) Development (Cambridge, England). 140(8):1819-29.

Silvério KG, Davidson KC, James RG, Adams AM, Foster BL, Nociti FH Jr, Somerman MJ, Moon RT. Wnt/β-catenin pathway regulates bone morphogenetic protein (BMP2)-mediated differentiation of dental follicle cells. (2012) Journal of periodontal research. 47(3):309-19.

Camp ND, James RG, Dawson DW, Yan F, Davison JM, Houck SA, Tang X, Zheng N, Major MB, Moon RT. Wilms tumor gene on X chromosome (WTX) inhibits degradation of NRF2 protein through competitive binding to KEAP1 protein. (2012) The Journal of biological chemistry. 287(9):6539-50.

Biechele TL, Kulikauskas RM, Toroni RA, Lucero OM, Swift RD, James RG, Robin NC, Dawson DW, Moon RT, Chien AJ. Wnt/β-catenin signaling and AXIN1 regulate apoptosis triggered by inhibition of the mutant kinase BRAFV600E in human melanoma. (2012) Science signaling. 5(206):ra3.

James RG, Davidson KC, Bosch KA, Biechele TL, Robin NC, Taylor RJ, Major MB, Camp ND, Fowler K, Martins TJ, Moon RT. WIKI4, a novel inhibitor of tankyrase and Wnt/ß-catenin signaling. (2012) PloS one. 7(12):e50457.

James RG, Biechele TL, Conrad WH, Camp ND, Fass DM, Major MB, Sommer K, Yi X, Roberts BS, Cleary MA, Arthur WT, MacCoss M, Rawlings DJ, Haggarty SJ, Moon RT. Bruton's tyrosine kinase revealed as a negative regulator of Wnt-beta-catenin signaling. (2009) Science signaling. 2(72):ra25.

James RG, Conrad WH, Moon RT. Beta-catenin-independent Wnt pathways: signals, core proteins, and effectors. (2008) Methods in molecular biology (Clifton, N.J.). 468:131-44.

James RG, Kamei CN, Wang Q, Jiang R, Schultheiss TM. Odd-skipped related 1 is required for development of the metanephric kidney and regulates formation and differentiation of kidney precursor cells. (2006) Development (Cambridge, England). 133(15):2995-3004.

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© 2016 by Rich James.