*** Click to learn more
The James lab uses a variety of techniques, depending on what question we are trying to answer. To learn about the signaling status of immune cells, we use quantitative proteomics. To determine how treatment with a targeted therapy alters sensitivity to other drugs, we use high throughput small molecule screening. To assess the impact of genetic variants on immune cell function, we introduce these using genome engineering. In most cases, projects in the lab will involve all of these techniques in order to satisfy our quest to understand how biochemical mechanisms contribute to immunological disease.